P-TYPE CALCIUM CHANNELS BLOCKED BY THE SPIDER TOXIN OMEGA-AGA-IVA

被引：839

作者：

MINTZ, IM

VENEMA, VJ

SWIDEREK, KM

LEE, TD

BEAN, BP

ADAMS, ME

机构：

[1] UNIV CALIF RIVERSIDE,DEPT ENTOMOL,RIVERSIDE,CA 92521

[2] HARVARD UNIV,SCH MED,DEPT NEUROBIOL,BOSTON,MA 02115

[3] CITY HOPE NATL MED CTR,BECKMAN RES INT,DIV IMMUNOL,DUARTE,CA 91010

来源：

NATURE | 1992年 / 355卷 / 6363期

关键词：

D O I：

10.1038/355827a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

VOLTAGE-DEPENDENT calcium channels mediate calcium entry into neurons, which is crucial for many processes in the brain including synaptic transmission, dendritic spiking, gene expression and cell death 1-5. Many types of calcium channels exist in mammalian brains 6-19, but high-affinity blockers are available for only two types, L-type channels (targeted by nimodipine and other dihydropyridine channel blockers 20-22) and N-type channels (targeted by omega-conotoxin 22-26). In a search for new channel blockers, we have identified a peptide toxin from funnel web spider venom, omega-Aga-IVA, which is a potent inhibitor of both calcium entry into rat brain synaptosomes and of 'P-type' calcium channels 8 in rat Purkinje neurons. omega-Aga-IVA will facilitate characterization of brain calcium channels resistant to existing channel blockers and may assist in the design of neuroprotective drugs.

引用

页码：827 / 829

页数：3

共 47 条

[1] 2 CLASSES OF CHANNEL-SPECIFIC TOXINS FROM FUNNEL WEB SPIDER VENOM [J].