ANIMAL-EXPERIMENTS ON THE ALLERGENICITY OF D-LIMONENE - THE CITRUS SOLVENT

被引：57

作者：

KARLBERG, AT ^{[1
]}

BOMAN, A ^{[1
]}

MELIN, B ^{[1
]}

机构：

[1] NATL BOARD OCCUPAT SAFETY & HLTH, ORGAN CHEM SECT, S-17184 SOLNA, SWEDEN

来源：

ANNALS OF OCCUPATIONAL HYGIENE | 1991年 / 35卷 / 04期

关键词：

D O I：

10.1093/annhyg/35.4.419

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

With the increasing use of d-limonene as a substitute for chlorinated hydrocarbons. chlorofluorocarbons (CFC) and other organic solvents, a demand has arisen for more knowledge of the health effects of this substance. The aim of the present study was to investigate the allergenic effect of d-limonene on skin. The sensitizing potential of d-limonene and the influence of air exposure on its allergenicity were studied in guineapigs. d-Limonene of high purity gave no significant allergic reactions, while d-limonene exposed to air for 2 months sensitized the animals. Gas chromatographic analyses indicated that the content of limonene oxide in limonene increased with prolonged air exposure. It is concluded that allergenic compounds are formed from d-limonene upon prolonged air exposure. Products containing d-limonene should therefore be kept in cold storage in closed vessels. Manual handling should be avoided, or gloves worn, in order to reduce the risk of sensitization.

引用

页码：419 / 426

页数：8

共 25 条

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