SEVERE GENERALIZED DYSTONIA ASSOCIATED WITH A MOSAIC PATTERN OF STRIATAL GLIOSIS

被引:36
作者
GIBB, WRG
KILFORD, L
MARSDEN, CD
机构
[1] Parkinson's Disease Society Brain Bank, Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London
关键词
CALBINDIN; DYSTONIA; HUNTINGTONS DISEASE; HYPOXIA; NEUROACANTHOCYTOSIS; STRIATUM;
D O I
10.1002/mds.870070305
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
A mosaic pattern of striatal pathology is described in a male who developed severe generalised dystonia from the age of 10 years, and died at the age of 18 years. There was no family history of dystonia, and extensive investigations during his life failed to identify a cause for the dystonia. The caudate nucleus and putamen showed a network of cell loss and gliosis surrounding islands of preserved striatum. Dorsal parts showed confluent gliosis, and ventral parts were spared. The pattern suggested a correlation with patch-matrix organisation, but there was no correlation with the distribution of calbindin immunoreactive cells, which are present in the matrix of the classical striosome-matrix organisation. The pathological findings were unlike those in status marmoratus, perinatal hypoxia-ischaemia, Huntington's disease, and neuroacanthocytosis, but similar to those reported in a 44-year-old man with predominantly cranial dystonia.
引用
收藏
页码:217 / 223
页数:7
相关论文
共 26 条
[1]  
Altrocchi PH., Spontaneous oral‐facial dyskinesia, Arch Neurol, 26, pp. 506-512, (1972)
[2]  
Altrocchi PH, Forno LS., Spontaneous oral‐facial dyskinesia: neuropathology of a case, Neurology, 33, pp. 802-805, (1983)
[3]  
Kiyama H, Seto-Ohshima A, Emson PC., Calbindin D<sub>28k</sub> as a marker for the degeneration of the striatonigral pathway in Huntington's disease, Brain Res, 525, pp. 209-214, (1990)
[4]  
Richfield EK, Twyman R, Berent S., Neurological syndrome following bilateral damage to the head of the caudate nuclei, Ann Neurol, 22, pp. 768-771, (1987)
[5]  
Gibb WRG, Lees AJ, Marsden CD., Pathological report of four patients presenting with cranial dystonias, Mov Disord, 3, pp. 211-221, (1988)
[6]  
Zweig RM, Hedreen JC., Jankel WR, Casanova MF, Whitehouse PJ, Price DL., Pathology in brainstem regions of individuals with primary dystonia, Neurology, 38, pp. 702-706, (1988)
[7]  
Kulisevsky J, Marti MJ, Ferrer I, Tolosa E., Meige syndrome: neuropathology of a case, Movement Disorders, 3, pp. 170-175, (1988)
[8]  
Mark MH, Schwarz KO, Duvoisin RC., Lewy bodies in Meige's syndrome, Neurology, 40, (1990)
[9]  
Jankovic J, Svendsen CN, Bird ED., Brain neurotransmitters in dystonia, N Engl J Med, 316, pp. 278-279, (1987)
[10]  
Tarlov E., On the problem of the pathology of spasmodic torticollis in man, J Neurol Neurosurg Psychiatry, 33, pp. 457-463, (1970)