B-Z CONFORMATIONAL TRANSITION AND HYDRATION OF POLY (DC-DG).POLY (DC-DG) IN FIBERS

被引：8

作者：

ALBISER, G

PREMILAT, S

机构：

[1] Laboratoire de Biophysique Moléculaire, UA CNRS 494, Faculté des Sciences, 54506 Vandoeuvre les Nancy

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 1992年 / 14卷 / 03期

关键词：

POLY(DC-DG).POLY(DC-DG); B-Z HELICAL TRANSITION; HYDRATION; X-RAY DIFFRACTION; FIBER DIMENSIONS;

D O I：

10.1016/S0141-8130(05)80006-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The B-Z transition of poly(dC-dG).poly(dC-dG) has been studied by fibre X-ray diffraction and measurement of fibre dimensions. The polymorphism of the Z form is well observed as a function of variations of the r.h. (relative humidity). The Z to B transition is obtained at very high r.h. values. The cooperative transition from B to Z is associated with a disorganization of the fibre. Details about the hydration of the polynucleotide during conformational transitions are presented and it is shown that a nucleotide in Z form can be associated with up to 16 water molecules and up to 22 when in the B form.

引用

页码：161 / 165

页数：5

共 29 条

[1] INFLUENCE OF A MECHANICAL TENSION ON THE B-A AND B-C CONFORMATIONAL TRANSITIONS IN DNA FIBERS [J].