LOCALIZATION OF THE GENE (LAMA4) TO CHROMOSOME-6Q21 AND ISOLATION OF A PARTIAL CDNA-ENCODING A VARIANT LAMININ-A CHAIN

被引：47

作者：

RICHARDS, AJ ^{[1
]}

ALIMARA, L ^{[1
]}

CARTER, NP ^{[1
]}

LLOYD, JC ^{[1
]}

LEVERSHA, MA ^{[1
]}

POPE, FM ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,DEPT PATHOL,CAMBRIDGE CB2 1QP,ENGLAND

来源：

GENOMICS | 1994年 / 22卷 / 01期

关键词：

D O I：

10.1006/geno.1994.1372

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Laminin is a basement membrane glycoprotein composed of three nonidentical chains, A, B1, and B2. Variant chains such as merosin and S-laminin have been found in different tissues. We have isolated a cDNA encoding a novel laminin A variant that hybridizes to a 6.45-kb mRNA. Using amplification of genomic DNA and flow-sorted chromosomes we have assigned the gene (LAMA4) for this new laminin A variant to chromosome 6. Fluorescence in situ hybridization of a YAC clone further localized the gene to 6q21. (C) 1994 Academic Press, Inc.

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页码：237 / 239

页数：3

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