LEUKOCYTE ADHESION MOLECULES AS A COFACTOR IN AIDS - BASIC SCIENCE AND PILOT-STUDY

被引:5
作者
ALLEN, AD
HARTT, DN
HECHINGER, MK
SLATTERY, MJ
CHESSON, CV
VIDIKAN, P
DYN, C
机构
[1] CYTO DYN NEW MEXICO INC,SANTA FE,NM 87501
[2] UNIV SO CALIF,SCH MED,FLOW CYTOMETRY LAB,LOS ANGELES,CA
[3] UNIV SO CALIF,SCH MED,DIV DERMATOL,LOS ANGELES,CA
关键词
D O I
10.1016/0306-9877(95)90065-9
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
It is well known that the AIDS pandemic is a consequence of pandemic HIV infection. However, Koch's postulates are not satisfied for two reasons: 1) AIDS cannot be experimentally produced in animals susceptible to HIV infection and 2) some people have AIDS (idiopathic CD4(+) T lymphocytopenia) in the absence of HIV infection. It follows that there is a human immunologic cofactor (HIC) that causes AIDS when certain other conditions are satisfied, and the most common of these other conditions (but not the only one) is HIV infection. Results from microbiology make leukocyte adhesion molecules a good candidate for the HIC. We have tested this hypothesis with a pilot study in which a small number of patients with HIV disease were infused with a monoclonal mouse antibody (MmAb) directed against an LFA-1 adhesion epitope, and then with F(ab) and F(ab)(2)' fragments that bind to the same epitope but are nonimmunogenic. Both agents reduced peripheral viral burden significantly but fragments were more effective in this respect than the MmAb due to the mitogenic properties of the latter. For the same reason, only the MmAb were highly effective in raising circulating levels of single and double-marked CD4(+) T lymphocytes, with a correlated resolution of cutaneous anergy.
引用
收藏
页码:164 / 168
页数:5
相关论文
共 15 条
[1]  
CAVALLIN F, 1993, CLIN EXP IMMUNOL, V93, P51
[2]   LABORATORY MONITORING OF THERAPY WITH OKT3 AND OTHER MURINE MONOCLONAL-ANTIBODIES [J].
COLVIN, RB ;
PREFFER, FI .
CLINICS IN LABORATORY MEDICINE, 1991, 11 (03) :693-714
[3]   REGULATION OF HIV PRODUCTION BY BLOOD MONONUCLEAR-CELLS FROM HIV-INFECTED DONORS .2. HIV-1 PRODUCTION DEPENDS ON T-CELL MONOCYTE INTERACTION [J].
DIEGEL, ML ;
MORAN, PA ;
GILLILAND, LK ;
DAMLE, NK ;
HAYDEN, MS ;
ZARLING, JM ;
LEDBETTER, JA .
AIDS RESEARCH AND HUMAN RETROVIRUSES, 1993, 9 (05) :465-473
[4]  
FROST SDW, 1994, J ACQ IMMUN DEF SYND, V7, P236
[5]   ONTOGENY OF T-CELL PRECURSORS - A MODEL FOR THE INITIAL-STAGES OF HUMAN T-CELL DEVELOPMENT [J].
HAYNES, BF ;
DENNING, SM ;
SINGER, KH ;
KURTZBERG, J .
IMMUNOLOGY TODAY, 1989, 10 (03) :87-91
[6]  
HAYNES BF, 1988, J EXP MED, V268, P1061
[7]  
KNICKER WT, 1984, ANN ALLERGY, V52, P75
[8]   INACTIVATED POLIO VACCINE HYPERIMMUNIZATION IN ADULTS WITH HIV DISEASE - A PLACEBO-CONTROLLED STUDY [J].
MATHISEN, GE ;
ALLEN, AD .
AIDS, 1992, 6 (07) :737-738
[9]   A NOVEL EPITOPE OF THE LFA-1 ANTIGEN WHICH CAN DISTINGUISH KILLER EFFECTOR AND SUPPRESSOR CELLS IN HUMAN CD8 CELLS [J].
MORIMOTO, C ;
RUDD, CE ;
LETVIN, NL ;
SCHLOSSMAN, SF .
NATURE, 1987, 330 (6147) :479-482
[10]  
MULLER KE, 1994, VET QUART, V16, P65