THE AMPLIFYING EFFECT OF BETA-AMYLOID ON CELLULAR CALCIUM SIGNALING IS REDUCED IN ALZHEIMERS-DISEASE

被引：22

作者：

ECKERT, A

FORSTL, H

HARTMANN, H

CZECH, C

MONNING, U

BEYREUTHER, K

MULLER, WE

机构：

[1] CENT INST MENTAL HLTH,DEPT PSYCHOPHARMACOL,D-68159 MANNHEIM,GERMANY

[2] CENT INST MENTAL HLTH,DEPT PSYCHIAT,D-68159 MANNHEIM,GERMANY

[3] UNIV HEIDELBERG,CTR MOLEC BIOL,D-69120 HEIDELBERG,GERMANY

来源：

NEUROREPORT | 1995年 / 6卷 / 08期

关键词：

BETA-AMYLOID; HUMAN LYMPHOCYTES; CALCIUM SIGNALING; ALZHEIMERS DISEASE; APOLIPOPROTEIN E;

D O I：

10.1097/00001756-199505300-00031

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE amplifying effect of beta-amyloid fragment 25-35 (beta A25-35) on the mitogen-induced rise of free intracellular calcium in circulating lymphocytes was strongly reduced in 24 patients with Alzheimer's disease when compared with elderly, non-demented controls. Low beta-amyloid responses were significantly correlated with the presence of the apolipoprotein E epsilon 4 allele, suggesting a dose effect.

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页码：1199 / 1202

页数：4

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