DURATION OF ACTION OF A SINGLE-DOSE OF AZELASTINE IN PATIENTS WITH CHRONIC ASTHMA

被引：4

作者：

CHERVINSKY, P

GROSSMAN, J

FREITAG, JJ

机构：

[1] Allergy and Asthma Center, North Dartmouth, MA

[2] Albany Medical College Allergy Division, Albany, NY

[3] Wallace Laboratories, Princeton, NJ

来源：

JOURNAL OF ASTHMA | 1995年 / 32卷 / 02期

关键词：

D O I：

10.3109/02770909509083235

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The aim of this double-blind, multicenter trial was to determine the duration of bronchodilating activity of a single 4-mg dose of azelastine in chronic asthmatics. Eligible patients had an FEV(1) of 40-79% of predicted value with demonstrated reversibility of airway obstruction. A single dose of azelastine 4 mg resulted in rapid onset of bronchodilating activity with a 12-hr duration of action as demonstrated by a clinically and statistically significant mean percent improvement in FEV(1), from hours 2-12. As an overall measure of improvement in FEV(1), the area under the curve was statistically significantly greater for azelastine than for placebo. Mean improvements in symptom severity in the azelastine group exceeded those for placebo at all observations points. No serious adverse experiences were associated with azelastine.

引用

页码：141 / 145

页数：5

共 13 条

[1]

Diamantis W., Harrison J.E., Melton J., Perhach J.L., Sofia R.D., vivo and in vitro H1 antagonist properties of azelastine, Pharmacologist, 23, (1981)

[2]

Chand N., Nolan K., Diamantis W., Perhach J.L., Sofia R.D., Inhibition of leukotriene (SRS-A) mediated allergic bronchospasm by azelastine, a novel, orally effective antiasthmatic drug, J Allergy Clin Immunol, 71, (1983)

[3]

Chand N., Nolan K., Diamantis W., Inhibition of leukotriene (SRS-A)-mediated acute lung anaphylaxis by azelastine in guinea pigs, Allergy, 41, (1986)

[4]

Chand N., Pillar J., Diamantis W., Inhibition of allergic histamine release from rat peritoneal mast cells by azelastine, Int Arch Allergy Appl Immunol, 86, (1988)

[5]

Fischer B., Schmutzler W., Inhibition by azelastine of the immunologically induced histamine release from isolated guinea pig mast cells, Arzneim Forsch, 31, (1981)

[6]

Chand N., Pillar J., Nolan K., Inhibition of 5-HETE, LTB4 and LTC4 synthesis by azelastine and its d-and -isomers in rat mixed peritoneal cells, Am Rev Respir Dis, 135, (1987)

[7]

Kemp J.P., Meltzer E.O., Orgel H.A., Welch M.J., Bucholtz G.A., Middleton E., Spector S.L., Newton J.J., Perhach J.L., A dose-response study of the bronchodilator action of azelastine in asthma, J Allergy Clin Immunol, 79, (1987)

[8]

Holgate S.T., Hardy C.C., Robinson C., Agius R.M., Howarth P.H., The mast cell as a primary effector cell in the pathogenesis of asthma, J Allergy Clin Immunol, 77, (1986)

[9]

Holgate S.T., Finnerty J.P., Antihistamines in asthma, J Allergy Clin Immunol, 83, Pt 2, (1989)

[10]

Cockcroft D.W., Ruffin R.M., Dolovich J., Hargreave F.E., Allergen-induced increase in non-allergic bronchial reactivity, Clin Allergy, 7, (1977)

← 1 2 →