EFFECT OF DOMOIC ACID ON METABOLISM OF 5-HYDROXYTRYPTAMINE IN RAT-BRAIN

被引：11

作者：

ARIAS, B ^{[1
]}

ARUFE, M ^{[1
]}

ALFONSO, M ^{[1
]}

DURAN, R ^{[1
]}

机构：

[1] UNIV VIGO,FAC CIENCIAS,DEPT BIOL FUNDAMENTAL,E-36200 VIGO,SPAIN

来源：

NEUROCHEMICAL RESEARCH | 1995年 / 20卷 / 04期

关键词：

DOMOIC ACID; SEROTONIN; RAT BRAIN;

D O I：

10.1007/BF00973094

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Domoic acid (Dom) is a neurotoxic secondary amino acid that interacts with the glutamate receptors, producing neurological problems. In the present work, we study the effects of Dom on the levels of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in discrete rat brain regions. The effects of Dom on the brain metabolism of serotonin are also discussed in this paper. Dom stimulates the rat brain serotoninergic system, increasing differentially the synthesis and the catabolism of 5-HT and the elimination of 5-HIAA.

引用

页码：401 / 404

页数：4

共 13 条

[1] REGULATION OF 5-HYDROXYTRYPTAMINE SYNTHESIS [J].

BENDER, DA .

PROCEEDINGS OF THE NUTRITION SOCIETY, 1978, 37 (02) :159-165

[2]

Bird C. J., 1989, WORLD AQUACULTURE, V20, P40

[3] DOMOIC AND QUISQUALIC ACIDS AS POTENT AMINO-ACID EXCITANTS OF FROG AND RAT SPINAL NEURONS [J].

BISCOE, TJ ;

EVANS, RH ;

HEADLEY, PM ;

MARTIN, M ;

WATKINS, JC .

NATURE, 1975, 255 (5504) :166-167

[4]

COLLINS RC, 1987, NEUROTOXINS THEIR PH, P1

[5] DOMOIC ACID, THE ALLEGED MUSSEL TOXIN, MIGHT PRODUCE ITS NEUROTOXIC EFFECT THROUGH KAINATE RECEPTOR ACTIVATION - AN ELECTROPHYSIOLOGICAL STUDY IN THE RAT DORSAL HIPPOCAMPUS [J].

DEBONNEL, G ;

BEAUCHESNE, L ;

DEMONTIGNY, C .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1989, 67 (01) :29-33

[6] REDUCED NEUROEXCITATORY EFFECT OF DOMOIC ACID FOLLOWING MOSSY FIBER DENERVATION OF THE RAT DORSAL HIPPOCAMPUS - FURTHER EVIDENCE THAT TOXICITY OF DOMOIC ACID INVOLVES KAINATE RECEPTOR ACTIVATION [J].

DEBONNEL, G ;

WEISS, M ;

DEMONTIGNY, C .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1989, 67 (08) :904-908

[7]

IVERSON F, 1989, 16S1E CAN DIS WKLY R, P15

[8]

KILPATRICK IC, 1986, J NEUROCHEM, V46, P1865

[9]

Neff N H, 1968, Adv Pharmacol, V6, P97

[10]

PERL TM, 1989, 16S1E CAN DIS WKLY R, P7

← 1 2 →