STATUS OF ANTIOXIDANT SYSTEMS IN HUMAN CARCINOMA OF UTERINE CERVIX

被引：26

作者：

BALASUBRAMANIYAN, N ^{[1
]}

SUBRAMANIAN, S ^{[1
]}

GOVINDASAMY, S ^{[1
]}

机构：

[1] UNIV MADRAS, DEPT BIOCHEM, MADRAS 600025, TAMIL NADU, INDIA

来源：

CANCER LETTERS | 1994年 / 87卷 / 02期

关键词：

FREE RADICALS; ANTIOXIDANTS; ANTIOXIDANT ENZYMES; LIPID PEROXIDATION; UTERINE CERVICAL CARCINOMA;

D O I：

10.1016/0304-3835(94)90221-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lipid peroxides, glutathione content and the activities of antioxidant enzymes were estimated in patients who had carcinoma of the uterine cervix, and the values were compared with those of normal. The results showed a remarkable reduction in glutathione content and in the activities of catalase and superoxide dismutase in neoplastic tissue in stages II, III and IV (P < 0.001) whereas the activities of glutathione peroxidase and glutathione reductase were significantly lower in stage III and IV patients than that of normal controls. The tissue level of lipid peroxides and the activity of glutathione-S-transferase were found to be significantly higher than that of normals from stage II onwards. These observations suggested the impaired antioxidant status in carcinoma of the uterine cervix.

引用

页码：187 / 192

页数：6

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