A RADIATION HYBRID MAP OF 506 STS MARKERS SPANNING HUMAN-CHROMOSOME-11

被引：173

作者：

JAMES, MR

RICHARD, CW

SCHOTT, JJ

YOUSRY, C

CLARK, K

BELL, J

TERWILLIGER, JD

HAZAN, J

DUBAY, C

VIGNAL, A

AGRAPART, M

IMAI, T

NAKAMURA, Y

POLYMEROPOULOS, M

WEISSENBACH, J

COX, DR

LATHROP, GM

机构：

[1] CTR ETUD POLYMORPHISME HUMAIN,PARIS,FRANCE

[2] UNIV PITTSBURGH,DEPT PSYCHIAT,PITTSBURGH,PA 15213

[3] UNIV PITTSBURGH,DEPT HUMAN GENET,PITTSBURGH,PA 15213

[4] JOHN RADCLIFFE HOSP,INST MOLEC MED,OXFORD OX3 9DU,ENGLAND

[5] COLUMBIA UNIV,DEPT GENET & DEV,NEW YORK,NY 10032

[6] INST PASTEUR,CNRS,URA 1445,PARIS,FRANCE

[7] GENETHON,F-91000 EVRY,FRANCE

[8] JAPANESE FDN CANC RES,INST CANC,DEPT BIOCHEM,TOKYO 170,JAPAN

[9] NIH,NATL CTR HUMAN GENOME RES,BETHESDA,MD 20892

[10] STANFORD UNIV,DEPT GENET,STANFORD,CA 94305

[11] INSERM,U358,PARIS,FRANCE

来源：

NATURE GENETICS | 1994年 / 8卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/ng0994-70

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We present a high resolution radiation hybrid map-of human chromosome 11 using 506 sequence tagged sites (STSs) scored on a panel of 86 radiation hybrids. The 506 STSs fall into 299 unique positions (average resolution of about 480 kilobases (kb)) that span pericentric markers unambiguously assigned to the short or long arm. The map contains most genes (125) and expressed sequence tags (26) currently assigned to chromosome the whole chromosome. A subset of 260 STSs (143 positions) form a framework map that has a resolution of approximately 1 megabase between adjacent positions and is ordered with odds of at least 1,000:1. The centromere was clearly defined with 11 and more than half of the STSs are polymorphic microsatellite loci. These markers and the map can be used for high resolution physical and genetic mapping.

引用

页码：70 / 76

页数：7

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