P-GLYCOPROTEIN IN ADULT HEMATOLOGIC MALIGNANCIES

被引：70

作者：

MARIE, JP ^{[1
]}

机构：

[1] HOP HOTEL DIEU,CLAUDE BERNARD RES UNIT TREATMENT HEMATOL MALIGNA,F-75181 PARIS,FRANCE

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 1995年 / 9卷 / 02期

关键词：

D O I：

10.1016/S0889-8588(18)30094-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hematologic malignancies are the most extensively studied tumors for drug resistance, but wide discrepancies within multidrug resistance (MDR1) gene expression in the same tumors underlined the absence of ''gold standard'' techniques. in acute myelogeneous leukemia, several studies showed that MDR1 gene overexpression is correlated with treatment failure. Although not clearly demonstrated in other hematologic malignancies, tumoral cells from already treated patients usually expressed P-glycoprotein more frequently.

引用

页码：239 / 249

页数：11

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