REACTIONS TO PERORAL PROPYLENE-GLYCOL

被引：54

作者：

HANNUKSELA, M

FORSTROM, L

机构：

[1] Department of Dermatology, University Central Hospital, Oulu

[2] Department of Dermatology, University Central Hospital, Helsinki

来源：

CONTACT DERMATITIS | 1978年 / 4卷 / 01期

关键词：

Drug reactions; glycols; propylene glycol;

D O I：

10.1111/j.1600-0536.1978.tb03719.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

A peroral challenge lest with 2–15 ml of propylene glycol (PG) was made in 38 patients with allergic‐type epicutaneous test reactions to PG. Eight of 10 patients with a positive epicutaneous reaction to 2% PG and seven of the other 28 patients with a positive epicutaneous reaction to 10–100 % PG developed an exanthem 3–16 h after ingestion of the drug. In all hut one case the rash disappeared within 24–48 h without any medication. In one ease the exanthem was treated with prednisone for 4 days, and the symptoms disappeared gradually in 6 days. None of the 20 control patients had skin symptoms, Nausea, vertigo and a curious sensation were recorded in four PG‐sensitive patients and in three control patients. These symptoms were apparently due to the general pharmacodynamic effects of PG and they were regarded as non‐allergic in nature. It was concluded that PG is a potential allergen and it must he added to the list of causes of drug exuathems Copyright © 1978, Wiley Blackwell. All rights reserved

引用

页码：41 / 45

页数：5

共 8 条

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[4] Fisher A.A., Pacher F., Kanof N.B., Allergic contact dermatitis due to ingredients of vehicles, Archives of Dermatology, 104, pp. 286-290, (1971)
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[6] Staples R., Misher A., Wardell J., Gastrointestinal irritant effect of glycerin as compared with sorbitol and propylene glycol in rats and dogs, Journal of Pharmaceutical Sciences, 56, (1967)
[7] Stecher P.G., The Merck index. An Encyclopedia of Chemical and Drugs, (1968)
[8] Warshaw T.G., Herrmann F., Studies of skin reactions to propylene glycol,, Journal of Investigative Dermatology,, 19, pp. 423-430, (1952)

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