A NEW TOCOLYTIC AGENT - DEVELOPMENT OF AN OXYTOCIN ANTAGONIST FOR INHIBITING UTERINE CONTRACTIONS

被引：36

作者：

WILSON, L ^{[1
]}

PARSONS, MT ^{[1
]}

OUANO, L ^{[1
]}

FLOURET, G ^{[1
]}

机构：

[1] NORTHWESTERN UNIV,SCH MED,DEPT PHYSIOL,CHICAGO,IL 60611

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 1990年 / 163卷 / 01期

关键词：

Oxytocin antagonist; preterm labor; tocolytic; uterine contractions;

D O I：

10.1016/S0002-9378(11)90698-X

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

A potent oxytocin antagonist has been developed and tested on both the rat and human uterus. In the rat the oxytocin antagonist: (1) inhibited in vitro and in vivo uterine contractions in the nonpregnant animal in response to exogenous oxytocin, (2) inhibited milk letdown, and (3) disrupted the progress of labor. In addition, the oxytocin antagonist inhibited the in vitro contractile response to exogenous oxytocin of human myometrial tissue obtained by cesarean section at term. The results of these studies suggest that the oxytocin antagonist can be used to study the role of oxytocin in labor and has the potential of inhibiting preterm labor in humans. © 1990, Mosby. All rights reserved.

引用

页码：195 / 202

页数：8

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