REMOVAL OF BENZYL-TYPE PROTECTING GROUPS FROM PEPTIDES BY CATALYTIC TRANSFER HYDROGENATION WITH FORMIC-ACID

被引：275

作者：

ELAMIN, B ^{[1
]}

ANANTHARAMAIAH, GM ^{[1
]}

ROYER, GP ^{[1
]}

MEANS, GE ^{[1
]}

机构：

[1] OHIO STATE UNIV,DEPT BIOCHEM,COLUMBUS,OH 43210

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1979年 / 44卷 / 19期

关键词：

D O I：

10.1021/jo01333a048

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Summary: Formic acid is shown to be a particularly effective hydrogen donor for the rapid removal of peptide benzyl and benzyloxycarbonyl protecting groups by catalytic transfer hydrogenation.Sir: Catalytic transfer hydrogenation has been shown to be a useful procedure for the removal of benzyl and benzyloxycarbonyl protecting groups in peptide synthesis.1-4 Good yields of deprotected products have been obtained under relatively mild conditionsusing both. © 1979, American Chemical Society. All rights reserved.

引用

页码：3442 / 3444

页数：3

共 15 条

[1] ANANTHARAMAIAH GM, 1978, INDIAN J CHEM B, V16, P797
[2] ANANTHARAMAIAH GM, 1977, J CHEM SOC P1, V5, P490
[3] ANANTHARAMAIAH GM, 1977, 26TH C INT UN PUR AP, P1123
[4] ANWER MK, 1978, SYNTHESIS-STUTTGART, P75
[5] BENOITON L, 1964, CAN J CHEM, V42, P2343
[6] SYNTHESIS OF PEPTIDES BY AMINOLYSIS OF NITROPHENYL ESTERS
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[J]. NATURE, 1955, 175 (4459) : 685 - 685
[7] CATALYTIC TRANSFER HYDROGENATION
BRIEGER, G
NESTRICK, TJ
[J]. CHEMICAL REVIEWS, 1974, 74 (05) : 567 - 580
[8] RAPID REMOVAL OF PROTECTING GROUPS FROM PEPTIDES BY CATALYTIC TRANSFER HYDROGENATION WITH 1,4-CYCLOHEXADIENE
FELIX, AM
HEIMER, EP
LAMBROS, TJ
TZOUGRAKI, C
MEIENHOFER, J
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1978, 43 (21) : 4194 - 4196
[9] GREENSTEIN JP, 1961, CHEM AMINO ACIDS, V3, P1233
[10] NEW SYNTHETIC SUBSTRATES FOR PEPSIN
INOUYE, K
VOYNICK, IM
DELPIERRE, GR
FRUTON, JS
[J]. BIOCHEMISTRY, 1966, 5 (07) : 2473 - +

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