ACTH THERAPY IN INFANTILE SPASMS - RELATIONSHIP BETWEEN DOSE OF ACTH AND INITIAL EFFECT OR LONG-TERM PROGNOSIS

被引：36

作者：

ITO, M

OKUNO, T

FUJII, T

MUTOH, K

OGURO, K

SHIRAISHI, H

SHIRASAKA, Y

MIKAWA, H

机构：

[1] Department of Pediatrics, Kyoto University, Kyoto

[2] Department of Faculty of Medicine, Kyoto University, Kyoto

来源：

PEDIATRIC NEUROLOGY | 1990年 / 6卷 / 04期

关键词：

D O I：

10.1016/0887-8994(90)90114-G

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The relationship between the dose of ACTH and the initial effect was investigated in 41 children with infantile spasms. More than 0.015 mg (0.6 IU)/kg/day of ACTH was needed for a good initial response of seizures and electroencephalographic abnormalities. The relationship between the dose of ACTH and long-term prognosis was investigated in 29 patients. There was no relationship between the daily or total ACTH dosage, provided the dose was > 0.015 mg (0.6 IU)/kg/day, and the outcome of seizures and electroencephalographic abnormalities; however, ACTH 0.04-0.06 mg (1.6-2.4 IU)/kg/day and a total ACTH dose of 1.1-1.5 mg (44-60 IU)/kg resulted in better mental development than smaller doses of ACTH. Side effects of ACTH increased with dosage. Too small or too large a dose of ACTH does not lead to better mental development. The proper dose of ACTH should be used with careful attention to potential side effects. © 1990.

引用

页码：240 / 244

页数：5

共 19 条

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