BLOCKADE OF NEUROPEPTIDE Y-INDUCED POTENTIATION OF NORADRENALINE-EVOKED VASOCONSTRICTION BY D-MYO-INOSITOL-1.2.6-TRISPHOSPHATE(PP56) IN RABBIT FEMORAL ARTERIES

被引：19

作者：

ADAMSSON, M

EDVINSSON, L

机构：

[1] UNIV LUND HOSP,DEPT INTERNAL MED,S-22185 LUND,SWEDEN

[2] MALMO GEN HOSP,DEPT EXPTL RES,S-21401 MALMO,SWEDEN

来源：

NEUROPEPTIDES | 1991年 / 19卷 / 01期

关键词：

D O I：

10.1016/0143-4179(91)90068-T

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Neuropeptide Y (NPY) potentiates noradrenaline (NA)-evoked constriction of circular segments of the rabbit femoral artery. The potentiation occurs exclusively in the lower concentration-range of the agonist NA (10(-8) -3 x 10(-7) M) without any change in maximum contractile effect. NPY per se is without contractile effect in the rabbit femoral artery. The recently developed substance, D-myo-inositol-1.2.6.-trisphosphate (PP56), which is an isomer of inositol-1.4.5-trisphosphate, is without effect per se on the rabbit femoral artery, nor does it affect NA-induced contractions. However, it was found to completely antagonize NPY-induced potentiation of the NA concentration-response curve.

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页码：13 / 16

页数：4

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