ANTIHEPATITIC ACTIVITY OF GINSENOSIDE RO

被引：51

作者：

MATSUDA, H

SAMUKAWA, K

KUBO, M

机构：

来源：

PLANTA MEDICA | 1991年 / 57卷 / 06期

关键词：

PANAX-GINSENG; GINSENOSIDE RO; OLEANANETYPE SAPONIN; D-GALACTOSAMINE-INDUCED HEPATITIS; CARBON TETRACHLORIDE-INDUCED HEPATITIS; CONNECTIVE TISSUE;

D O I：

10.1055/s-2006-960198

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ginsenoside Ro, an oleanane-type saponin has been screened for activity in experimental models of acute and chronic hepatitis. Ginsenoside Ro (50 and 200 mg/kg, p.o.) inhibited the increase of serum glutamic oxaloacetic transminase (s-GOT) and serum glutamic pyruvic transaminase (s-GPT) levels in D-galactosamine (GalN)- and carbon tetrachloride (CC14)-induced acute hepatitic rats. Ginsenoside Ro inhibited the increase of connective tissue in the liver of CCl4-induced chronic hepatitic rats. Ginsenoside Ro showed a stronger inhibitory effect on the GalN-induced acute hepatitic model than those of the aglycone of ginsenoside Ro, oleanolic acid, or glycyrrhizic acid and its aglycone, glycyrrhetinic acid.

引用

页码：523 / 526

页数：4

共 8 条

[1]

HIKINO H, 1985, PLANTA MED, V57, P62

[2]

Kaulla KN, 1958, AM J CLIN PATHOL, V29, P104

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