REGULATION OF FISH GLYCOLYSIS GLUCONEOGENESIS - ROLE OF FRUCTOSE 2,6 P2 AND PFK-2

1. Fructose 2,6 P2 and PFK-2 have a key role in the regulation of glycolysis-gluconeogenesis in fish. 2. PFK-1 and FBPase-1, as in mammals, are the target enzymes for fructose 2,6 P2, this in turn may be controlled by glucagon and insulin. 3. PFK-2 from fish liver seems to be a bifunctional enzyme regulated by phosphorylation/dephosphorylation. 4. Starvation, refeeding, diet composition and anoxia studies provide a general view of the fructose 2,6 P2 fish system from which the differences between fish and mammal glycolysis-gluconeogenesis may be ascertained.