SIMULTANEOUS DETERMINATION OF TRIMIPRAMINE AND ITS MAJOR METABOLITES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：4

作者：

GULAID, AA ^{[1
]}

JAHN, GA ^{[1
]}

MASLEN, C ^{[1
]}

DENNIS, MJ ^{[1
]}

机构：

[1] RHONE POULENC RORER LTD,DEPT BIOPHARM,DAGENHAM RM10 7XS,ESSEX,ENGLAND

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 566卷 / 01期

关键词：

D O I：

10.1016/0378-4347(91)80128-Y

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Trimipramine is a tricyclic antidepressant drug often assayed by gas chromatographic or gas chromatographic-mass spectrometry techniques. A high-performance liquid chromatographic method with electrochemical detection is described for the assay of trimipramine and its major metabolites, monodesmethyltrimipramine and 2-hydroxytrimipramine, in plasma. The method is sensitive, accurate and robust and thus suitable for routinely assaying samples following single doses of trimipramine to man. The assay was applied to plasma samples obtained following a single 50-mg dose of trimipramine to healthy volunteers.

引用

页码：228 / 233

页数：6

共 12 条

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