MHC CLASS-II BETA-CHAIN EXPRESSION IN THE RAINBOW-TROUT

被引：53

作者：

JUULMADSEN, HR ^{[1
]}

GLAMANN, J ^{[1
]}

MADSEN, HO ^{[1
]}

SIMONSEN, M ^{[1
]}

机构：

[1] STATE UNIV HOSP COPENHAGEN,RIGSHOSP,TISSUE TYPING LAB,COPENHAGEN,DENMARK

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1992年 / 35卷 / 06期

关键词：

D O I：

10.1111/j.1365-3083.1992.tb02976.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A cDNA clone corresponding to the MHC class II beta-chain of the rainbow trout (Oncorhynchus mykiss) has been isolated and used in restriction fragment length polymorphism (RFLP) studies in a family of full siblings of rainbow trout. A very simple RFLP pattern was detected, suggesting segregation of a homozygote AA genotype and a heterozygote AB genotype. The MHC class II beta-chain of the rainbow trout seems to be transcribed in the same type of cells as class II genes of higher vertebrates even though the cDNA clone recognizes atypical messenger sizes of 2.2 kb and 3.6 kb in the analysed family. Surprisingly the transcripts seem to be allele-specific for the assigned genotypes.

引用

页码：687 / 694

页数：8

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