DRAMATIC RESPONSE OF A METASTATIC CARCINOID-TUMOR TO A COMBINATION OF INTERFERON AND OCTREOTIDE

被引：46

作者：

JOENSUU, H ^{[1
]}

KATKA, K ^{[1
]}

KUJARI, H ^{[1
]}

机构：

[1] UNIV TURKU,DEPT PATHOL,SF-20500 TURKU 50,FINLAND

来源：

ACTA ENDOCRINOLOGICA | 1992年 / 126卷 / 02期

关键词：

D O I：

10.1530/acta.0.1260184

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The combination of alpha-interferon and octreotide has rarely been tested in the treatment of carcinoid syndrome. We describe a patient who was moribund when treated with interferon alone, but enjoyed a dramatic response leading to disappearance of all symptoms, normalization of dU-5-HIAA, and restoration of his normal life-style when octreotide was initiated. Neither interferon nor octreotide could be withdrawn without reappearance of the symptoms, suggesting that the combination of alpha-interferon and octreotide may have synergistic effects in carcinoid syndrome.

引用

收藏

页码：184 / 185

页数：2

相关论文

共 12 条

[1] OCTREOTIDE - A REVIEW OF ITS PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES, AND THERAPEUTIC POTENTIAL IN CONDITIONS ASSOCIATED WITH EXCESSIVE PEPTIDE SECRETION [J].

BATTERSHILL, PE ;

CLISSOLD, SP .

DRUGS, 1989, 38 (05) :658-702

[2] TREATMENT OF DISSEMINATED ILEAL AND COECAL CARCINCOID TUMORS WITH RECOMBINANT ALPHA-INTERFERON [J].

DOBERAUER, C ;

NIEDERLE, N ;

KLOKE, O ;

KURSCHEL, E ;

SCHMIDT, CG .

ONKOLOGIE, 1987, 10 (06) :340-344

[3] RECOMBINANT ALPHA-2-INTERFERON WITH OR WITHOUT HEPATIC-ARTERY EMBOLIZATION IN THE TREATMENT OF MIDGUT CARCINOID-TUMORS - A PRELIMINARY-REPORT [J].

HANSSEN, LE ;

SCHRUMPF, E ;

KOLBENSTVEDT, AN ;

TAUSJO, J ;

DOLVA, LO .

ACTA ONCOLOGICA, 1989, 28 (03) :439-443

[4]

MATON P, 1989, ANN INTERN MED, V110, P35

[5] THERAPY OF METASTATIC CARCINOID-TUMOR AND THE MALIGNANT CARCINOID-SYNDROME WITH RECOMBINANT LEUKOCYTE-A INTERFERON [J].

MOERTEL, CG ;

RUBIN, J ;

KVOLS, LK .

JOURNAL OF CLINICAL ONCOLOGY, 1989, 7 (07) :865-868

[6] INTERFERON TREATMENT IN PATIENTS WITH MALIGNANT CARCINOIDS [J].

NOBIN, A ;

LINDBLOM, A ;

MANSSON, B ;

SUNDBERG, M .

ACTA ONCOLOGICA, 1989, 28 (03) :445-449

[7] TREATMENT OF MALIGNANT CARCINOID-TUMORS - A RANDOMIZED CONTROLLED-STUDY OF STREPTOZOCIN PLUS 5-FU AND HUMAN-LEUKOCYTE INTERFERON [J].

OBERG, K ;

NORHEIM, I ;

ALM, G .

EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY, 1989, 25 (10) :1475-1479

[8]

OBERG K, 1986, CANCER TREAT REP, V70, P1297

[9] TREATMENT OF MALIGNANT CARCINOID-TUMORS WITH RECOMBINANT INTERFERON ALFA-2B - DEVELOPMENT OF NEUTRALIZING INTERFERON ANTIBODIES AND POSSIBLE LOSS OF ANTITUMOR-ACTIVITY [J].

OBERG, K ;

ALM, G ;

MAGNUSSON, A ;

LUNDQVIST, G ;

THEODORSSON, E ;

WIDE, L ;

WILANDER, E .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1989, 81 (07) :531-535

[10]

SMFITH DB, 1987, CANCER GREAT REP, V71, P1265