TUMOR-NECROSIS-FACTOR-ALPHA ACTS AS AN AUTOCRINE 2ND SIGNAL WITH GAMMA-INTERFERON TO INDUCE NITRIC-OXIDE IN GROUP-B STREPTOCOCCUS-TREATED MACROPHAGES

被引：23

作者：

GOODRUM, KJ

DIERKSHEIDE, J

YODER, BJ

机构：

来源：

INFECTION AND IMMUNITY | 1995年 / 63卷 / 09期

关键词：

D O I：

10.1128/IAI.63.9.3715-3717.1995

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nitric oxide production by mouse macrophages treated with group B streptococci and gamma interferon was inhibited by cytochalasin B or by antibody neutralization of macrophage-derived tumor necrosis factor alpha. Phagocytosis-induced tumor necrosis factor alpha is responsible for group B streptococcus-induced nitric oxide production in interferon-treated macrophages.

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页码：3715 / 3717

页数：3

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