TRANSCRIPTION COMPLEX STABILITY AND CHROMATIN DYNAMICS IN-VIVO

被引：416

作者：

WIJGERDE, M ^{[1
]}

GROSVELD, F ^{[1
]}

FRASER, P ^{[1
]}

机构：

[1] NATL INST MED RES,GENE STRUCT & EXPRESS LAB,LONDON NW7 1AA,ENGLAND

来源：

NATURE | 1995年 / 377卷 / 6546期

关键词：

D O I：

10.1038/377209a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Distant regulatory sequences affect transcription through long-range chromatin interactions. Visualization of transcriptional activity of genes that compete for distant elements, using the globin locus as a model, has revealed the dynamics of chromatin Interactions in vivo. Multiple genes appear to be transcribed alternately rather than at the same time to generate several messenger RNAs in one cell. The regulator may stably complex with one gene at a time and switch back and forth between genes in a flip-flop mechanism.

引用

页码：209 / 213

页数：5

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