EFFECTS OF DNA-BINDING DRUGS ON T4 DNA-LIGASE

被引：16

作者：

MONTECUCCO, A

PEDRALINOY, G

SPADARI, S

LESTINGI, M

CIARROCCHI, G

机构：

来源：

BIOCHEMICAL JOURNAL | 1990年 / 266卷 / 02期

关键词：

D O I：

10.1042/bj2660379

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A number of DNA intercalating and externally binding drugs have been found to inhibit nick sealing, cohesive and blunt end ligation, AMP-dependent DNA topoisomerization and EDTA-induced DNA nicking mediated by bacteriophage T4 DNA ligase. The inhibition seems to arise from drug-substrate interaction so that formation of active DNA-Mg2+-AMP-enzyme complex is impaired while assembled and active complexes are not disturbed by drug binding to the substrate.

引用

页码：379 / 384

页数：6

共 20 条

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