ANAPHYLACTOID REACTIONS DURING HEMODIALYSIS ON AN69 MEMBRANES IN PATIENTS RECEIVING ACE INHIBITORS

被引：144

作者：

TIELEMANS, C

MADHOUN, P

LENAERS, M

SCHANDENE, L

GOLDMAN, M

VANHERWEGHEM, JL

机构：

[1] UNIV LIBRE BRUXELLES,HOP ERASME,DEPT NEPHROL DIALYSIS & TRANSPLANTAT,ROUTE LENNIK 808,B-1070 BRUSSELS,BELGIUM

[2] UNIV LIBRE BRUXELLES,HOP ERASME,DEPT IMMUNOL,B-1070 BRUSSELS,BELGIUM

来源：

KIDNEY INTERNATIONAL | 1990年 / 38卷 / 05期

关键词：

D O I：

10.1038/ki.1990.301

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

We report five life-threatening anaphylactoid reactions occurring within the very first minutes of hemodialysis on polyacrylonitrile (AN69) capillary dialyzers in three patients receiving ACE inhibitors. Such reactions were not observed either in patients treated with ACE inhibitors but dialyzed on other membranes (N = 9), nor in patients on AN69 who did not receive ACE inhibitors (N = 19). These anaphylactoid reactions could be due to bradykinin accumulation, as a result of both increased synthesis - by interaction of blood with the AN69 polymer - and catabolism blockade by ACE inhibitors.

引用

页码：982 / 984

页数：3

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