REPEATED CULTURED EPIDERMAL ALLOGRAFTS IN THE TREATMENT OF CHRONIC LEG ULCERS OF VARIOUS ORIGINS

被引：51

作者：

BEELE, H

NAEYAERT, JM

GOETEYN, M

DEMIL, M

KINT, A

机构：

[1] STATE UNIV GHENT HOSP, DEPT DERMATOL, DE PINTELAAN 185, B-9000 GHENT, BELGIUM

[2] BELGIAN NATL FUND SCI RES, LOUVAIN, BELGIUM

来源：

DERMATOLOGICA | 1991年 / 183卷 / 01期

关键词：

CULTURED EPIDERMAL ALLOGRAFTS; ULCERS; HEALING PATTERN;

D O I：

10.1159/000247628

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Twelve patients with 16 leg ulcers, existing for at least 3 months and not responsive to conventional inpatient therapy of at least 3 weeks, were treated with repeated applications of cultured allogenic keratinocyte sheets. A marked decrease in size was seen in all ulcers but 2. Complete closure of the ulcer was seen in 62% of the ulcers within 8 weeks. Healing was due to enhanced granulation and increased epithelialization, starting from the periphery of the wound. This edge effect suggests that the epidermal allografts act by stimulation of migration and/or multiplication of the acceptor's keratinocytes, rather than by take of the allograft.

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页码：31 / 35

页数：5

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