TRANSIENT AND LONG-LASTING BENEFICIAL BEHAVIORAL-EFFECTS OF GRAFTS IN THE DAMAGED HIPPOCAMPUS OF RAT

被引：12

作者：

SPRICK, U

机构：

[1] C. and O. Vogt-Institute of Brain Research, University of Düsseldorf, Düsseldorf

来源：

BEHAVIOURAL BRAIN RESEARCH | 1991年 / 42卷 / 02期

关键词：

NEURAL TRANSPLANTATION; HIPPOCAMPUS; NEUROTOXIC LESION; ALTERNATION BEHAVIOR; ALCOVE-TEST;

D O I：

10.1016/S0166-4328(05)80010-5

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

One week after receiving bilateral neurotoxic lesions of their dorsal hippocampi, adult Wistar rats were bilaterally grafted with fetal hippocampal tissue suspensions. The behavior of the animals was testing during a period of 5 months after grafting to determine changes in lesion-induced deficits. The transplants caused various behavioral effects with different time courses. Grafted animals showed an early, however, transient amelioration of behavioral deficits in a T-maze alternation task and they performed with a long-lasting improvement in the alcove-test. Transplant histology demonstrated high levels of AChE-activity in patches correlating with clusters or rudimentary layers of pyramidal neurons.

引用

页码：187 / 199

页数：13

共 45 条

[1] BRAIN TRANSPLANTS ENHANCE RATHER THAN REDUCE THE IMPAIRMENT OF SPATIAL MEMORY AND OLFACTION IN BULBECTOMIZED RATS [J].