SYNTHESIS AND DNA-BINDING PROPERTIES OF POLYAMINE ANALOGS

被引：60

作者：

EDWARDS, ML

SNYDER, RD

STEMERICK, DM

机构：

[1] Marion Merrell Dow Research Institute, Cincinnati, Ohio 45215

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 34卷 / 08期

关键词：

D O I：

10.1021/jm00112a016

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a series of novel polyamine analogues is reported. The DNA binding of these compounds and a variety of other polyamines were compared with their IC50 values against HeLa cell. There seemed to be no apparent correlation between the DNA binding and toxicity against HeLa cells.

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页码：2414 / 2420

页数：7

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