CA2+-INDUCED CHANGES IN THE BARRIER PROPERTIES OF CARDIOLIPIN-PHOSPHATIDYLCHOLINE BILAYERS

被引：39

作者：

MANDERSLOOT, JG

GERRITSEN, WJ

LEUNISSENBIJVELT, J

VANECHTELD, CJA

NOORDAM, PC

DEGIER, J

机构：

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1981年 / 640卷 / 01期

关键词：

D O I：

10.1016/0005-2736(81)90536-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A selective increase in permeability is induced in cardiolipin/phosphatidylcholine bilayers at Ca2+ concentrations of 1-3 mM. At higher concentrations of Ca2+ the permeability barrier is completely destroyed. The selective increase in permeability is correlated with the formation of lipid particles visualized by freeze-fracture EM and an isotropic signal in 31P-NMR spectra. Lowering the Ca2+ concentration shows reduction in permeability but the formation of the lipid particles is a non-reversible process. At higher Ca2+ concentrations, 31P-NMR spectra and freeze-fracture results indicate the formation of the hexagonal phase, explaining the disappearance of the permeability barrier.

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页码：106 / 113

页数：8

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