MOLECULAR CHARACTERIZATION OF AN OPERON REQUIRED FOR PERTUSSIS TOXIN SECRETION

被引：235

作者：

WEISS, AA

JOHNSON, FD

BURNS, DL

机构：

[1] CTR BIOL EVALUAT & RES,DIV BACTERIAL PROD,8800 ROCKVILLE PIKE,BETHESDA,MD 20892

[2] VIRGINIA COMMONWEALTH UNIV,DEPT MICROBIOL & IMMUNOL,RICHMOND,VA 23298

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 07期

关键词：

D O I：

10.1073/pnas.90.7.2970

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mutants of Bordetella pertussis which are defective in secretion of pertussis toxin were isolated and characterized. The region of the B. pertussis chromosome identified by mutagenesis as playing a role in transport of pertussis toxin was sequenced. Analysis of this region revealed eight open reading frames, seven of which predict a protein exhibiting homology with one of the VirB proteins of Agrobacterium tumefaciens, which are involved in the transport of the T-DNA molecule across bacterial and plant membranes. Thus a set of accessory proteins are most likely involved in the secretion of pertussis toxin, and these proteins appear to be members of a family of proteins involved in the secretion of macromolecules from bacteria.

引用

页码：2970 / 2974

页数：5

共 24 条

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