POTENTIATION OF ANTIFUNGAL ACTIVITY OF SESQUITERPENE DIALDEHYDES AGAINST CANDIDA-ALBICANS AND 2 OTHER FUNGI

被引：48

作者：

KUBO, I

HIMEJIMA, M

机构：

[1] Division of Entomology and Parasitology, College of Natural Resources, University of California, Berkeley, 94720, California

来源：

EXPERIENTIA | 1992年 / 48卷 / 11-12期

关键词：

POLYGODIAL; WARBURGANAL; ANTIFUNGAL ACTIVITY; CANDIDA-ALBICANS; SACCHAROMYCES-CEREVISIAE; PITYROSPORUM-OVALE; ENHANCING EFFECT; ANTIOXIDANTS; VITAMIN-C; BHA; ANETHOLE;

D O I：

10.1007/BF01948015

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The antifungal activity of two drimane sesquiterpene dialdehydes, polygodial (1) and warburganal (2), alone and in combination with several other substances, was examined against three fungi, Candida albicans, Saccharomyces cerevisiae and Pityrosporum ovale employing a broth dilution method. Anethole significantly synergized the activity of the two sesquiterpenoids against C. albicans and S. cerevisiae; however, it had only an additive effect against P. ovale. By contrast, two antioxidants, ascorbic acid (vitamin C) and BHA (butylated hydroxyanisole), noticeably enhanced the activity of the sesquiterpenoids against P. ovale, but had no effect against C. albicans and S. cerevisiae.

引用

页码：1162 / 1164

页数：3

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