ELECTROPHYSIOLOGICAL CHARACTERIZATION OF A TTX-SENSITIVE SODIUM CURRENT IN NATIVE XENOPUS OOCYTES

被引:10
作者
BOURINET, E
NARGEOT, J
CHARNET, P
机构
[1] CRBM, CNRS (UPR9008)-INSERM (U249), 34033 Montpellier, Route de Mende
关键词
D O I
10.1098/rspb.1992.0140
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We have studied a fast inward current expressed in oocytes from one Xenopus laevis. This current was characterized as a sodium current. It was activated by depolarizations to -50 mV or higher, peaked within 3-5 ms, and then decayed following a mono-exponential timecourse. When clamped at different holding potentials, the current displayed voltage-dependent inactivation with a V0,5 of -51 mV. The channel responsible for this Na+ entry was blocked by tetrodotoxin with a K0.5 of 8 nm, and was resistant to block by lidocaine at concentrations up to 100 mum. The pharmacological similarities between neuronal and oocyte sodium channels suggest that the two channels share a conserved structure.
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收藏
页码:127 / 132
页数:6
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