IDENTIFICATION OF A GENE, MLL, THAT SPANS THE BREAKPOINT IN 11Q23 TRANSLOCATIONS ASSOCIATED WITH HUMAN LEUKEMIAS

被引：504

作者：

ZIEMINVANDERPOEL, S

MCCABE, NR

GILL, HJ

ESPINOSA, R

PATEL, Y

HARDEN, A

RUBINELLI, P

SMITH, SD

LEBEAU, MM

ROWLEY, JD

DIAZ, MO

机构：

[1] UNIV CHICAGO,DEPT MED,HEMATOL ONCOL SECT,CHICAGO,IL 60637

[2] UNIV CHICAGO,DEPT MOLEC GENET & CELL BIOL,CHICAGO,IL 60637

[3] UNIV CHICAGO,DEPT PEDIAT,CHICAGO,IL 60637

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 23期

关键词：

LYMPHOID; MYELOID LEUKEMIAS; GENE MAPPING; INSITU HYBRIDIZATION; TRANSCRIPT ANALYSIS; PHORBOL ESTER INDUCTION;

D O I：

10.1073/pnas.88.23.10735

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recurring chromosomal translocations involving chromosome 11, band q23, have been observed in acute lymphoid leukemias and especially in acute myeloid leukemias. We recently showed that breakpoints in four 11q23 translocations, t(4;11)(q21;q23), t(6;11)(q27;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13.3), were contained within a yeast artificial chromosome clone bearing the CD3D and CD3G gene loci. We have identified within the CD3 yeast artificial chromosome a transcription unit that spans the breakpoint junctions of the 4;11, 9;11, and 11;19 translocations, and we describe two other, related transcripts that are upregulated in the RS4;11 cell line. We have named this gene MLL (myeloid/lymphoid, or mixed-lineage, leukemia).

引用

页码：10735 / 10739

页数：5

共 25 条

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