CHEMOTAXIS OF POLYMORPHONUCLEAR NEUTROPHILS (PMN) IN PATIENTS SUFFERING FROM RECURRENT INFECTION

被引：26

作者：

BRENNEIS, H

SCHMIDT, A

BLAASMAUTNER, P

WORNER, I

LUDWIG, R

HANSCH, GM

机构：

[1] UNIV HEIDELBERG,INST IMMUNOL,W-6900 HEIDELBERG,GERMANY

[2] UNIV HEIDELBERG,KINDERKLIN,W-6900 HEIDELBERG,GERMANY

来源：

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 1993年 / 23卷 / 11期

关键词：

D O I：

10.1111/j.1365-2362.1993.tb01288.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

PMN function was tested in patients suffering from recurrent infections. In 65 out of 240 patients lack of oxygen radical production or reduced chemotactic activity was found. In most cases the reduction was transient and associated with clinical impairments of the patients. Only a few patients had primary cellular defects. In one of those patients the expression of beta 2 integrins was reduced, while PMN of the other patients expressed beta 2 integrins normally. Thus, cellular defects other than the reduced expression of beta 2 integrins might also result in impaired chemotactic activity.

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页码：693 / 698

页数：6

相关论文

共 45 条

[1] INFLUENZA-A VIRUS-INDUCED POLYMORPHONUCLEAR LEUKOCYTE DYSFUNCTION IN THE PATHOGENESIS OF EXPERIMENTAL PNEUMOCOCCAL OTITIS-MEDIA [J].

ABRAMSON, JS ;

GIEBINK, GS ;

QUIE, PG .

INFECTION AND IMMUNITY, 1982, 36 (01) :289-296

[2]

AGGARWAL J, 1985, J NATL MED ASSOC, V77, P928

[3] INHERITED DEFECT OF NEUTROPHIL MOBILITY IN SHWACHMAN SYNDROME [J].

AGGETT, PJ ;

HARRIES, JT ;

HARVEY, BAM ;

SOOTHILL, JF .

JOURNAL OF PEDIATRICS, 1979, 94 (03) :391-394

[4] ABNORMALITIES OF CHEMOTACTIC LYMPHOKINE SYNTHESIS AND MONONUCLEAR LEUKOCYTE CHEMOTAXIS IN WISKOTT-ALDRICH SYNDROME [J].

ALTMAN, LC ;

SNYDERMAN, R ;

BLAESE, RM .

JOURNAL OF CLINICAL INVESTIGATION, 1974, 54 (02) :486-493

[5] ABNORMALITIES OF POLYMORPHONUCLEAR LEUKOCYTE FUNCTION ASSOCIATED WITH A HERITABLE DEFICIENCY OF HIGH MOLECULAR-WEIGHT SURFACE GLYCOPROTEINS (GP138) - COMMON RELATIONSHIP TO DIMINISHED CELL ADHERENCE [J].

ANDERSON, DC ;

SCHMALSTIEG, FC ;

ARNAOUT, MA ;

KOHL, S ;

TOSI, MF ;

DANA, N ;

BUFFONE, GJ ;

HUGHES, BJ ;

BRINKLEY, BR ;

DICKEY, WD ;

ABRAMSON, JS ;

SPRINGER, T ;

BOXER, LA ;

HOLLERS, JM ;

SMITH, CW .

JOURNAL OF CLINICAL INVESTIGATION, 1984, 74 (02) :536-551

[6]

ANDERSON DC, 1985, FED PROC, V44, P2671

[7] BIOLOGICAL DEFENSE MECHANISMS - PRODUCTION BY LEUKOCYTES OF SUPEROXIDE A POTENTIAL BACTERICIDAL AGENT [J].

BABIOR, BM ;

KIPNES, RS ;

CURNUTTE, JT .

JOURNAL OF CLINICAL INVESTIGATION, 1973, 52 (03) :741-744

[8] CHEDIAK-HIGASHI SYNDROME - STUDIES IN 4 PATIENTS AND A REVIEW OF LITERATURE [J].

BLUME, RS ;

WOLFF, SM .

MEDICINE, 1972, 51 (04) :247-+

[9] NEUTROPHIL ACTIN DYSFUNCTION AND ABNORMAL NEUTROPHIL BEHAVIOR [J].

BOXER, LA ;

HEDLEYWH.T ;

STOSSEL, TP .

NEW ENGLAND JOURNAL OF MEDICINE, 1974, 291 (21) :1093-1099

[10] CHEMOTACTIC EFFECT OF MIXTURES OF ANTIBODY AND ANTIGEN ON POLYMORPHONUCLEAR LEUCOCYTES [J].

BOYDEN, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 1962, 115 (03) :453-&

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