TOXICOLOGICAL ANALYSIS OF WHOLE-BLOOD SAMPLES BY MEANS OF BOND-ELUT CERTIFY COLUMNS AND GAS-CHROMATOGRAPHY WITH NITROGEN-PHOSPHORUS DETECTION

被引：30

作者：

ZWEIPFENNING, PGM ^{[1
]}

WILDERINK, AHCM ^{[1
]}

HORSTHUIS, P ^{[1
]}

FRANKE, JP ^{[1
]}

DEZEEUW, RA ^{[1
]}

机构：

[1] UNIV GRONINGEN,CTR PHARM,9713 AW GRONINGEN,NETHERLANDS

来源：

JOURNAL OF CHROMATOGRAPHY A | 1994年 / 674卷 / 1-2期

关键词：

D O I：

10.1016/0021-9673(94)85219-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The application of Bond-Elut Certify solid-phase extraction columns to the systematic toxicological analysis of whole blood was evaluated. The reproducibility of the extraction was tested with thirteen drugs varying in physico-chemical properties. Analysis was performed with capillary gas chromatography with nitrogen-selective detection. The recoveries were reproducible, as long as other limiting factors, e.g., chromatographic behaviour or volatility, do not play a significant role. The effect of limiting chromatographic behaviour was studied in more detail with the more sensitive mass spectrometry with selected-ion monitoring after converting the extracted morphine into its ditrimethylsilyl derivative.

引用

页码：87 / 95

页数：9

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