MODULATION OF MAMMALIAN-CELL PROLIFERATION BY A MODIFIED TRANSFER-RNA BASE OF BACTERIAL ORIGIN

被引:23
作者
LANGGUT, W [1 ]
REISSER, T [1 ]
NISHIMURA, S [1 ]
KERSTEN, H [1 ]
机构
[1] NATL CANC CTR,DIV BIOL,CHUO KU,TOKYO,TOKYO,JAPAN
关键词
QUEUINE; CELL PROLIFERATION; HYPOXIA; ONCOGENIC TRANSFORMATION; TRANSFER-RNA MODIFICATION; AEROBIC GLYCOLYSIS;
D O I
10.1016/0014-5793(93)81627-C
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Addition of the q-base to q-deficient non-transformed mammalian cells stimulated their proliferation. The q-base also improved proliferation of some cancer-derived cell lines, but inhibited proliferation of others. The proliferation of HeLa-S3 carcinoma cells was stimulated by q under aerobic conditions, but was inhibited when the cells had shifted their energy metabolism towards glycolysis as the result of oxygen limitation. Q-deficient cells could not adapt their proliferation to the respective oxygen tension. The q-base stimulated the proliferation of non-transformed fibroblasts but inhibited proliferation of the same cell line, when aerobic glycolysis was increased after transformation with the ras gene. The results suggest that the q-base permits mammalian cells to adapt their proliferation to their specific metabolic state.
引用
收藏
页码:137 / 142
页数:6
相关论文
共 36 条
[1]   QUEUINE ANALOGS - THEIR SYNTHESIS AND INHIBITION OF GROWTH OF MOUSE L5178Y CELLS-INVITRO [J].
AKIMOTO, H ;
NOMURA, H ;
YOSHIDA, M ;
SHINDOOKADA, N ;
HOSHI, A ;
NISHIMURA, S .
JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (09) :1749-1753
[2]  
ANDERSON GR, 1981, J BIOL CHEM, V256, P583
[3]  
Bjork GR, 1992, TRANSFER RNA PROTEIN, P23
[4]  
BOHM P, 1988, MOL CELL BIOL LIFE S, V7, P117
[5]   CARBON METABOLISM IN EARLY AMPHIBIAN EMBRYOS [J].
DWORKIN, MB ;
DWORKINRASTL, E .
TRENDS IN BIOCHEMICAL SCIENCES, 1991, 16 (06) :229-234
[6]  
ELLIOT MS, 1984, CANCER RES, V44, P3515
[7]  
EMMERICH B, 1985, CANCER RES, V45, P4308
[8]   QUEUINE, THE Q-CONTAINING TRANSFER-RNAS AND THE ENZYMES RESPONSIBLE FOR THEIR FORMATION [J].
FARKAS, WR .
NUCLEOSIDES & NUCLEOTIDES, 1983, 2 (01) :1-20
[9]   QUEUINE, A TRANSFER-RNA ANTICODON WOBBLE BASE, MAINTAINS THE PROLIFERATIVE AND PLURIPOTENT POTENTIAL OF HL-60 CELLS IN THE PRESENCE OF THE DIFFERENTIATING AGENT 6-THIOGUANINE [J].
FRENCH, BT ;
PATRICK, DE ;
GREVER, MR ;
TREWYN, RW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (02) :370-374
[10]   NEW FUNCTION OF VITAMIN-B12 - COBAMIDE-DEPENDENT REDUCTION OF EPOXYQUEUOSINE TO QUEUOSINE IN TRANSFER-RNAS OF ESCHERICHIA-COLI AND SALMONELLA-TYPHIMURIUM [J].
FREY, B ;
MCCLOSKEY, J ;
KERSTEN, W ;
KERSTEN, H .
JOURNAL OF BACTERIOLOGY, 1988, 170 (05) :2078-2082