MODULATION OF MAMMALIAN-CELL PROLIFERATION BY A MODIFIED TRANSFER-RNA BASE OF BACTERIAL ORIGIN

被引：23

作者：

LANGGUT, W ^{[1
]}

REISSER, T ^{[1
]}

NISHIMURA, S ^{[1
]}

KERSTEN, H ^{[1
]}

机构：

[1] NATL CANC CTR,DIV BIOL,CHUO KU,TOKYO,TOKYO,JAPAN

来源：

FEBS LETTERS | 1993年 / 336卷 / 01期

关键词：

QUEUINE; CELL PROLIFERATION; HYPOXIA; ONCOGENIC TRANSFORMATION; TRANSFER-RNA MODIFICATION; AEROBIC GLYCOLYSIS;

D O I：

10.1016/0014-5793(93)81627-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Addition of the q-base to q-deficient non-transformed mammalian cells stimulated their proliferation. The q-base also improved proliferation of some cancer-derived cell lines, but inhibited proliferation of others. The proliferation of HeLa-S3 carcinoma cells was stimulated by q under aerobic conditions, but was inhibited when the cells had shifted their energy metabolism towards glycolysis as the result of oxygen limitation. Q-deficient cells could not adapt their proliferation to the respective oxygen tension. The q-base stimulated the proliferation of non-transformed fibroblasts but inhibited proliferation of the same cell line, when aerobic glycolysis was increased after transformation with the ras gene. The results suggest that the q-base permits mammalian cells to adapt their proliferation to their specific metabolic state.

引用

页码：137 / 142

页数：6

共 36 条

[1] QUEUINE ANALOGS - THEIR SYNTHESIS AND INHIBITION OF GROWTH OF MOUSE L5178Y CELLS-INVITRO [J].