DETERMINING OTITIS-MEDIA SEVERITY FROM MIDDLE-EAR FLUID ANALYSIS

被引:34
作者
JUHN, SK
GARVIS, WJ
LE, CT
LEES, CJ
KIM, CS
机构
[1] UNIV MINNESOTA,SCH MED,OTITIS MED RES CTR,MINNEAPOLIS,MN 55455
[2] UNIV MINNESOTA,SCH MED,DEPT OTOLARYNGOL,MINNEAPOLIS,MN 55455
[3] UNIV MINNESOTA,SCH PUBL HLTH,DIV BIOSTAT,MINNEAPOLIS,MN 55455
[4] SEOUL NATL UNIV,DEPT OTOLARYNGOL,SEOUL,SOUTH KOREA
关键词
COLLAGENASE; CYTOKINE; MIDDLE EAR FLUID; MYRINGOTOMY; OTITIS MEDIA; SEVERITY; TUMOR NECROSIS FACTOR;
D O I
10.1177/00034894941030S512
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Otitis media has a complex multifactorial pathogenesis, and the middle ear inflammatory response is typified by the accumulation of cellular and chemical mediators in middle ear effusion. However, specific biochemical and immunochemical factors that may be responsible for the severity or chronicity of odds media have not been identified. Identification of factors involved in chronicity appears to be an essential step in the treatment and ultimate prevention of chronic otitis media. We analyzed 70 effusion samples from patients 1 to 10 years of age who bad chronic odds media with effusion for two cytokines (interleukin-1 beta and tumor necrosis factor alpha) and total collagenase. The highest concentrations of all three inflammatory mediators were found in purulent otitis media, and concentrations were higher in younger than in older patients. Mediator concentrations were similar in samples obtained from patients having their first myringotomy for odds media with effusion and in those who had had multiple previous myringotomies. The multiresponse star, which incorporates several biochemical parameters in one graphic illustration, may best characterize the complex nature of middle ear inflammation.
引用
收藏
页码:43 / 45
页数:3
相关论文
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