BIOCHEMICAL MECHANISM OF DRUG RESISTANCE .7. INHIBITION OF OROTIC ACID METABOLISM BY 5-AZACYTIDINE IN LEUKEMIC MICE SENSITIVE AND RESISTANT TO 5-AZACYTIDINE

被引：47

作者：

VESELY, J

CIHAK, A

SORM, F

机构：

[1] Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Prague

来源：

BIOCHEMICAL PHARMACOLOGY | 1968年 / 17卷 / 04期

关键词：

D O I：

10.1016/0006-2952(68)90267-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Application of 5-azacytidine to leukemic AKR mice results in an inhibition of the utilization of orotic acid in the liver. In 5-azacytidine-sensitive animals, the inhibition is greater than in the resistant ones. Similarly, the excretion of orotic acid and orotidine in the urine is higher after application of 5-azacytidine in the sensitive animals. Cell-free extracts from leukemic cells, both sensitive and resistant to 5-azacytidine, showed a decreased activity of orotidylic acid decarboxylase after application of 5-azacytidine in vivo. The differences in the metabolism of orotate are related to the decreased ability of 5-azacytidine-resistant leukemic cells to convert 5-azacytidine to 5-azacytidine 5'-phosphate. © 1968.

引用

页码：519 / &

共 16 条

[1] INCORPORATION OF 5-AZACYTIDINE INTO LIVER RIBONUCLEIC ACIDS OF LEUKEMIC MICE SENSITIVE AND RESISTANT TO 5-AZACYTIDINE [J].

CIHAK, A ;

VESELY, J ;

SORM, F .

BIOCHIMICA ET BIOPHYSICA ACTA, 1965, 108 (03) :516-&

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