EVALUATION OF THE ANTI-ASTHMATIC POTENTIAL OF OXARBAZOLE IN GUINEA-PIGS

被引：6

作者：

MIELENS, ZE

机构：

来源：

PHARMACOLOGY | 1978年 / 17卷 / 06期

关键词：

D O I：

10.1159/000136873

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Oxarbazole, 9-benzoyl-2,3,4,9,-tetrahydro-6-methoxy-1H-carbazole-3-carboxylic acid, inhibited bronchoconstriction induced by a crude SRS-A preparation or by bradykinin in dose-related manner in anesthetized guinea pigs. Oxarbazole was ineffective against bronchoconstriction induced by histamine, carbachol, serotonin, or PGF(2α). Inhibition of bronchoconstriction induced by the crude SRS-A preparation by oxarbazole was unimpeded by the presence of β-adrenergic- or cholinergic-blocking agents, but it could be overcome by increased doses of the crude SRS-A preparation.

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页码：323 / 329

页数：7

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