SPIROMETRY IN AMYOTROPHIC LATERAL SCLEROSIS

被引：172

作者：

FALLAT, RJ ^{[1
]}

JEWITT, B ^{[1
]}

BASS, M ^{[1
]}

KAMM, B ^{[1
]}

NORRIS, FH ^{[1
]}

机构：

[1] PACIFIC MED CTR,INST MED SCI,2200 WEBSTER ST,SAN FRANCISCO,CA 94115

来源：

ARCHIVES OF NEUROLOGY | 1979年 / 36卷 / 02期

关键词：

D O I：

10.1001/archneur.1979.00500380044004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Clinical evaluation and pulmonary function tests were performed in 218 patients with motor neuron disease, mainly amyotrophic lateral sclerosis (ALS). Serial studies were obtained in 103 patients, in 31 until death from ALS. Most patients, regardless of the pattern of motor neuron involvement, had characteristic abnormalities in pulmonary function, including reduced forced vital capacity (FVC) and maximum voluntary ventilation (MVV). Reductions in the FVC and MVV to as low as 50% were commonly missed by clinical evaluators. Spirometry is therefore of value in detecting early involvement of respiratory neurons. Progressively greater reductions in the FVC and MVV in all the fatal cases indicate that serial spirometry has prognostic value in ALS. © 1979, American Medical Association. All rights reserved.

引用

页码：74 / 80

页数：7

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