GM ALLOTYPE GENES AND GENE DOSAGE AFFECTING BOTH IGG SUBCLASS AND IGE LEVELS IN ATOPIC PATIENTS

The imbalanced IgG subclass levels of 50 atopic patients with IgE > 600 kU/l reflected the Gm expression of the patients. IgG1 was significantly increased but only in patients with the phenotypes Gm(f,f,n,n) and Gm(a,a,″,″). The typical IgG4 increase was found in the most frequent Gm(f,f,n,n) and Gm(a,f,n,″) phenotypes. Significant increase of IgG2, IgG3 and IgG4 was found in patients homozygous for G2m(n) compared to those lacking this allotype. IgG2 decrease was found in those with the Gm(f,f,″,″) phenotype and IgG3 decrease in those with the Gm(a,a,″,″) phenotype. Also the IgE levels were influenced by the Gm allotypes with increased IgE levels in the G1m(f,f) patients compared to the G1m(a,a)patients.