VANADATE SELECTIVELY INHIBITS THE K-0(+)ACTIVATED NA+ EFFLUX IN SQUID AXONS

被引:43
作者
BEAUGE, L
DIPOLO, R
机构
[1] Department of Biophysics, University of Maryland School of Medicine, Baltimore
关键词
(Na[!sup]+[!/sup] + K[!sup]+[!/sup])-ATPase; (Squid axons); Na[!sup]+[!/sup] pump; Vanadate;
D O I
10.1016/0005-2736(79)90367-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The effects of internally applied 1 mM vanadate on the Na+ efflux in dialysed squid axons were found to depend on the presence of external K+. In K+-free artificial sea water, vanadate did not produce any change in the rate of Na+ efflux, whereas in the presence of 10 mM K+ the Na+ efflux was reduced to values even lower than those observed in the absence of K+ (inversion of the K+-free effect). In vanadate-poisoned axons, K+ and NH4+ at low concentrations activated Na+ efflux, but at high concentrations both cations were inhibitory. However, NH4+ was always a better activator and a poorer inhibitor than K+. © 1979.
引用
收藏
页码:220 / 223
页数:4
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