CHARACTERIZATION OF IMMATURE CD4+CD8-CD3- THYMOCYTES

被引：33

作者：

HUGO, P

WAANDERS, GA

SCOLLAY, R

PETRIE, HT

BOYD, RL

机构：

[1] MONASH UNIV, SCH MED, DEPT PATHOL & IMMUNOL, CLAYTON, VIC 3168, AUSTRALIA

[2] ROYAL MELBOURNE HOSP, WALTER & ELIZA HALL INST MED RES, PARKVILLE, VIC 3050, AUSTRALIA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1991年 / 21卷 / 03期

关键词：

D O I：

10.1002/eji.1830210346

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Previously we have described (Hugo, P. et al., Int. Immunol. 1990. 2: 209) an immature CD4+CD8-CD3- thymocyte subset which is thought to be the counterpart of the CD4-CD8+CD3- subset. In this study we show that the ontogeny of these two subsets is parallel in fetal thymic organ culture. Extensive phenotypic characterization of CD4+CD8-CD3- cells reveals that they closely resemble CD4-CD8+CD3- thymocytes being: HSA(high), Thy-1high, interleukin 2 receptor alpha chain negative, CD44-, H-2K +/-, CD5low, MEL-14low/intermediate, CD2+, LFA-1+ and MTS 35+. Finally, we show that the proportion of CD4+CD8-CD3- thymocytes is highly variable between mouse strains.

引用

页码：835 / 838

页数：4

共 27 条

[1] SEQUENTIAL-ANALYSIS OF THE THYMOCYTE DIFFERENTIATION IN FULLY ALLOGENEIC BONE-MARROW CHIMERA IN MICE .2. FURTHER CHARACTERIZATION OF THE CD4+ OR CD8+ SINGLE POSITIVE THYMOCYTES [J].