DOES EXPOSURE TO RUBELLA-VIRUS GENERATE ENDOCRINE AUTOIMMUNITY

被引:8
作者
BODANSKY, HJ
DEAN, BM
GRANT, PJ
MCNALLY, J
SCHWEIGER, MS
HAMBLING, MH
BOTTAZZO, GF
WALES, JK
机构
[1] Professorial Medical Unit, The General Infirmary, Leeds
[2] Department of Immunology, University College, Middlesex Hospital Medical Schools, London
[3] Department of Community Medicine, Meanwood Park Hospital, Leeds
[4] Department of Virology, P.H.L.S, Seacroft Hospital, Leeds
关键词
Aetiology; Immunology; Islet cell antibodies; Rubella; Type; 1; diabetes; Viral infection;
D O I
10.1111/j.1464-5491.1990.tb01458.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Rubella virus is a possible environmental agent which may be involved in triggering autoimmunity to pancreatic islet cells, leading to Type 1 diabetes. Autoantibody responses were determined in 239 10‐year‐old girls who received live attenuated rubella vaccine, of whom 61 (26%) had no pre‐existing rubella immunity. Islet cell antibodies (ICA > 5 Juvenile Diabetes Foundation (JDF) units) were present in seven (2.9%) girls before vaccination, and they appeared in three more 6 weeks after vaccination (4.2%). However, the ICA levels were low in all cases and of the three girls who developed ICA > 5 JDF units 6 weeks post‐vaccination, none had detectable ICA 18 months later. IgG‐insulin autoantibodies were present in 17 (7.1%) girls before vaccination, and their prevalence decreased after vaccination (5.4%). Thyroid antibodies (thyroglobulin and microsomal) were present in 2% and 1%, respectively, of the girls before vaccination and none appeared afterwards. Thus, rubella vaccination did not elicit widespread endocrine autoantibody production and viral triggering of endocrine autoimmunity in susceptible subjects remains an open question. 1990 Diabetes UK
引用
收藏
页码:611 / 614
页数:4
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