THE DOPAMINE-D1 RECEPTOR IS INVOLVED IN THE REGULATION OF REM-SLEEP IN THE RAT

被引:50
作者
TRAMPUS, M
FERRI, N
MONOPOLI, A
ONGINI, E
机构
[1] Research Laboratories, Schering-Plough S.p.A., Milan
关键词
REM (RAPID EYE MOVEMENT) SLEEP; DOPAMINE-D1; RECEPTORS; SKF38393; SCH23390; NEUROLEPTICS; EEG(RAT);
D O I
10.1016/0014-2999(91)90104-X
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The dopamine D1 receptor agonist, SKF 38393, and the D1 antagonist, SCH 23390, were studied for their effects on sleep in the rat. Over 6 h, SKF 38393 (0.1-10 mg/kg s.c.) dose dependently reduced the amount of rapid eye movement (REM) sleep and enhanced the duration of wakefulness. The drug affected REM at low doses (ED50 = 0.4 mg/kg) at which wakefulness was unchanged and the characteristic grooming behavior was not apparent. REM changes were characterized by a decrease in the number of episodes with no alteration of latency to the first episode. Over a very low dose range (0.003-0.3 mg/kg s.c.), SCH 23390 enhanced the amount of REM by increasing both number and average duration of episodes. There was also a moderate increase of non-REM sleep but the percent change was less marked than that occurring for REM. Given at 0.003 mg/kg, SCH 23390 prevented the REM changes induced by SKF 38393 (0.3-3 mg/kg). It is suggested that D1 receptors are involved in the regulation of the REM sleep process.
引用
收藏
页码:189 / 194
页数:6
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