(2'-5')OLIGOADENYLATE AND INTRACELLULAR IMMUNITY AGAINST RETROVIRUS INFECTION

被引：44

作者：

SCHRODER, HC

SUHADOLNIK, RJ

PFLEIDERER, W

CHARUBALA, R

MULLER, WEG

机构：

[1] UNIV MAINZ, INST PHYSIOL CHEM, ANGEW MOLEK BIOL ABT, DUESBERGWEG 6, W-6500 MAINZ, GERMANY

[2] TEMPLE UNIV, HLTH SCI CTR, SCH MED, DEPT BIOCHEM, PHILADELPHIA, PA 19140 USA

[3] UNIV CONSTANCE, FAK CHEM, W-7750 CONSTANCE, GERMANY

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1992年 / 24卷 / 01期

关键词：

D O I：

10.1016/0020-711X(92)90229-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. The double-stranded RNA-dependent 2',5'-oligoadenylate (2-5A) synthetase/ribonuclease L (RNase L) system plays an essential role in the establishment of the antiviral state of a cell exposed to virus infection. 2. Until recently, the application of 2-5A derivatives to reinforce this system seemed to be limited mainly due to the low specificity of RNase L for viral RNA. 3. Two new strategies have been developed which yield a selective antiviral effect of 2-5As at least against human immunodeficiency virus-1 (HIV-1) infection: (i) an "intracellular immunization" approach using 2-5A synthetase cDNA linked to HIV trans-acting response element (TAR) and (ii) inhibition of retroviral reverse transcriptase activity by 2-5A analogues.

引用

收藏

页码：55 / 63

页数：9

相关论文

共 97 条

[1] INFECTION WITH HUMAN T-LYMPHOTROPIC VIRUS TYPE-III AND LEUKOCYTE INTERFERON-PRODUCTION IN HOMOSEXUAL MEN [J].

ABB, J ;

PIECHOWIAK, H ;

ZACHOVAL, R ;

ZACHOVAL, V ;

DEINHARDT, F .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1986, 5 (03) :365-368

[2] SYNTHESIS OF THE COMPLETE TRANSACTIVATION GENE-PRODUCT OF HUMAN T-LYMPHOTROPIC VIRUS TYPE-III IN ESCHERICHIA-COLI - DEMONSTRATION OF IMMUNOGENICITY INVIVO AND EXPRESSION INVITRO [J].

ALDOVINI, A ;

DEBOUCK, C ;

FEINBERG, MB ;

ROSENBERG, M ;

ARYA, SK ;

WONGSTAAL, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (18) :6672-6676

[3] TRANS-ACTIVATOR GENE OF HUMAN T-LYMPHOTROPIC VIRUS TYPE-III (HTLV-III) [J].

ARYA, SK ;

GUO, C ;

JOSEPHS, SF ;

WONGSTAAL, F .

SCIENCE, 1985, 229 (4708) :69-73

[4] INTERFERON ACTION MAY BE MEDIATED BY ACTIVATION OF A NUCLEASE BY PPPA2'P5'A2'P5'A [J].

BAGLIONI, C ;

MINKS, MA ;

MARONEY, PA .

NATURE, 1978, 273 (5664) :684-687

[5] CLEAVAGE OF NASCENT REOVIRUS MESSENGER-RNA BY LOCALIZED ACTIVATION OF THE 2'-5'-OLIGOADENYLATE-DEPENDENT ENDORIBONUCLEASE [J].

BAGLIONI, C ;

DEBENEDETTI, A ;

WILLIAMS, GJ .

JOURNAL OF VIROLOGY, 1984, 52 (03) :865-871

[6] 2'5'OLIGO(A) POLYMERASE-ACTIVITY AND INHIBITION OF VIRAL-RNA SYNTHESIS IN INTERFERON-TREATED HELA-CELLS [J].

BAGLIONI, C ;

MARONEY, PA ;

WEST, DK .

BIOCHEMISTRY, 1979, 18 (09) :1765-1770

[7] GENE-THERAPY - INTRACELLULAR IMMUNIZATION [J].

BALTIMORE, D .

NATURE, 1988, 335 (6189) :395-396

[8] HIV-1 REVERSE-TRANSCRIPTASE SPECIFICALLY INTERACTS WITH THE ANTICODON DOMAIN OF ITS COGNATE PRIMER TRANSFER-RNA [J].

BARAT, C ;

LULLIEN, V ;

SCHATZ, O ;

KEITH, G ;

NUGEYRE, MT ;

GRUNINGERLEITCH, F ;

BARRESINOUSSI, F ;

LEGRICE, SFJ ;

DARLIX, JL .

EMBO JOURNAL, 1989, 8 (11) :3279-3285

[9] ANTIVIRAL ACTIVITY IN L1210 CELLS OF LIPOSOME-ENCAPSULATED (2'-5')OLIGO(ADENYLATE) ANALOGS [J].

BAYARD, B ;

LESERMAN, LD ;

BISBAL, C ;

LEBLEU, B .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1985, 151 (02) :319-325

[10] INCREASED STABILITY AND ANTIVIRAL ACTIVITY OF 2'-O-PHOSPHOGLYCERYL DERIVATIVES OF (2'-5')OLIGO(ADENYLATE) - ROLES OF PHOSPHODIESTERASES AND PHOSPHATASES IN (2'-5')OLIGO(ADENYLATE) CATABOLISM [J].

BAYARD, B ;

BISBAL, C ;

SILHOL, M ;

CNOCKAERT, J ;

HUEZ, G ;

LEBLEU, B .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1984, 142 (02) :291-298

← 1 2 3 4 5 6 7 8 9 10 →