SUSCEPTIBILITY OF HAEMOPHILUS-INFLUENZAE TO PIPERACILLIN-TAZOBACTAM COMBINATIONS - INTERPRETIVE CRITERIA AND QUALITY-CONTROL LIMITS FOR STANDARDIZED TESTS

被引:2
作者
BARRY, AL
FUCHS, PC
JORGENSEN, JH
TENOVER, FC
ALLEN, SD
HARDY, DJ
MCLAUGHLIN, JC
机构
[1] ST VINCENT HOSP & MED CTR,PORTLAND,OR 97225
[2] UNIV NEW MEXICO,MED CTR,ALBUQUERQUE,NM 87106
[3] UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284
[4] INDIANA UNIV,MED CTR,INDIANAPOLIS,IN 46202
[5] CTR DIS CONTROL,DIV ANTIMICROB INVEST,ATLANTA,GA 30333
[6] UNIV ROCHESTER,MED CTR,ROCHESTER,NY 14642
关键词
D O I
10.1128/JCM.31.3.751-753.1993
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
In vitro studies evaluated methods for testing the susceptibility of Haemophilus influenzae to piperacillin-tazobactam combinations. Ampicillin-resistant beta-lactamase-nonproducing strains of H. influenzae may be presumed to be relatively resistant to combinations of piperacillin-tazobactam, even though they frequently appear to be susceptible by disk diffusion methods. Other ampicillin-resistant or -susceptible strains were predictably susceptible; i.e., 130 such strains gave zones of inhibition greater-than-or-equal-to 26 mm in diameter, and MICs for these strains were less-than-or-equal-to 0.125/4.0 mug/ml (I less-than-or-equal-to 1.0/0.12 mug/ml when an 8:1 ratio was tested). A resistant category has yet to be defined. For quality control purposes, H. influenzae ATCC 49247 should give zones of inhibition 32 to 38 mm in diameter, and broth microdilution MICs should be 0.12/4.0 to 0.5/4.0 mug/ml.
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页码:751 / 753
页数:3
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