THE TRANSFORMATION OF NEOPINONE TO CODEINONE IN MORPHINE BIOSYNTHESIS PROCEEDS NONENZYMATICALLY

被引：26

作者：

GOLLWITZER, J ^{[1
]}

LENZ, R ^{[1
]}

HAMPP, N ^{[1
]}

ZENK, MH ^{[1
]}

机构：

[1] UNIV MUNICH,LEHRSTUHL PHARMAZEUT BIOL,KARLSTR 29,D-80333 MUNICH,GERMANY

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 36期

关键词：

D O I：

10.1016/S0040-4039(00)73838-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Thebaine after vinylether cleavage yields neopinone which exists in a chemical equilibrium with codeinone. It is demonstrated that codeine: NADP oxidoreductase in the presence of NADPH shifts this equilibrium quantitatively towards codeine.

引用

页码：5703 / 5706

页数：4

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