ISOLATION AND STRUCTURE ELUCIDATION OF 34-SULFATOBASTADIN-13, AN INHIBITOR OF THE ENDOTHELIN A RECEPTOR, FROM A MARINE SPONGE OF THE GENUS IANTHELLA

被引：35

作者：

GULAVITA, NK ^{[1
]}

WRIGHT, AE ^{[1
]}

MCCARTHY, PJ ^{[1
]}

POMPONI, SA ^{[1
]}

KELLYBORGES, M ^{[1
]}

CHIN, M ^{[1
]}

SILLS, MA ^{[1
]}

机构：

[1] CIBA GEIGY CORP,RES DEPT,SUMMIT,NJ 07901

来源：

JOURNAL OF NATURAL PRODUCTS | 1993年 / 56卷 / 09期

关键词：

D O I：

10.1021/np50099a026

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

34-Sulfatobastadin 13 [1] was isolated from the sponge lanthella sp. Its structure was elucidated by nmr techniques and chemical transformation to bastadin 13 [2]. Compound 1 weakly inhibited binding to the endothelin A receptor (ET(A)), while compound 2 inhibited growth of Bacillus subtilis.

引用

页码：1613 / 1617

页数：5

共 16 条

[1] BUTLER MS, 1991, AUST J CHEM, V4, P296
[2] A NEW BASTADIN FROM THE SPONGE PSAMMAPLYSILLA-PURPUREA
CARNEY, JR
SCHEUER, PJ
KELLYBORGES, M
[J]. JOURNAL OF NATURAL PRODUCTS, 1993, 56 (01): : 153 - 157
[3] MARINE NATURAL-PRODUCTS
FAULKNER, DJ
[J]. NATURAL PRODUCT REPORTS, 1991, 8 (02) : 97 - 147
[4] FULMOR W, 1970, Tetrahedron Letters, V52, P4551
[5] KAZLAUSKAS R, 1981, AUST J CHEM, V34, P765, DOI 10.1071/CH9810765
[6] BROMINATED TYROSINE-DERIVED METABOLITES FROM THE SPONGE IANTHELLA-BASTA
KAZLAUSKAS, R
LIDGARD, RO
MURPHY, PT
WELLS, RJ
[J]. TETRAHEDRON LETTERS, 1980, 21 (23) : 2277 - 2280
[7] SESTERTERPENE SULFATES FROM A SPONGE OF THE FAMILY HALICHONDRIIDAE
KERNAN, MR
FAULKNER, DJ
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (19) : 4574 - 4578
[8] IANTHELLINE, A NEW DERIVATIVE OF 3,5-DIBROMO-TYROSINE ISOLATED FROM THE SPONGE IANTHELLA-ARDIS FROM THE BAHAMAS
LITAUDON, M
GUYOT, M
[J]. TETRAHEDRON LETTERS, 1986, 27 (37) : 4455 - 4456
[9] Lurian V, 1986, ANTIBIOTICS LAB MED, P93
[10] CYTOTOXIC METABOLITES FROM THE SPONGE IANTHELLA-BASTA COLLECTED IN PAPUA-NEW-GUINEA
MIAO, S
ANDERSEN, RJ
ALLEN, TM
[J]. JOURNAL OF NATURAL PRODUCTS, 1990, 53 (06): : 1441 - 1446

← 1 2 →